If you take Depakote for the duration of pregnancy for almost any health care issue, your child is at risk for major start defects that influence the Mind and spinal wire (such as spina bifida or neural tube defects). These defects can commence in the primary thirty day period, even prior to deciding to know you are pregnant.

Contact a Health care service provider immediately When you've got any of those indications, particularly when They are really new, worse, or get worried you:

Basic information about the safe and helpful utilization of Depakote Medicines are sometimes prescribed for applications besides Individuals listed inside of a Medication Information. Don't use Depakote for just a condition for which it was not prescribed.

Table three lists cure-emergent adverse reactions which had been reported by ≥ five% of Depakotetreated patients and for which the incidence was larger than within the placebo group, in the placebo-managed trial of adjunctive therapy for treatment of sophisticated partial seizures.

The good thing about enhanced seizure Management with larger doses needs to be weighed versus the potential for a greater incidence of adverse reactions.

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Valproate is consequently contraindicated for prophylaxis of migraine problems in pregnant Women of all ages and in women of childbearing probable who are not working with successful contraception [see Contraindications (four)].

Desk 4 lists therapy-emergent adverse reactions which were claimed by ≥ five% of individuals within the high dose valproate team, and for which the incidence was higher than within the small dose team, within a controlled demo of Depakote monotherapy remedy of complicated partial seizures.

The concomitant utilization of valproate and propofol may possibly bring about elevated blood amounts of propofol. Decrease the dose of propofol when co-administering with valproate. Check patients intently for signs of more info elevated sedation or cardiorespiratory despair.

Propofol The concomitant utilization of valproate and propofol may bring about amplified blood levels of propofol. Decrease the dose of propofol when co-administering with valproate. Observe patients carefully for indications of amplified sedation or cardiorespiratory depression.

There are reports of acute or subacute encephalopathy while in the absence of elevated ammonia levels, elevated valproate amounts, or neuroimaging variations. The encephalopathy reversed partially or entirely just after valproate discontinuation.

have or Assume there is a genetic liver trouble caused by a mitochondrial condition like Alpers-Huttenlocher syndrome.

Applying DEPAKOTE with other medicines can result in significant Unwanted side effects. Do not start out or cease other medicines with out speaking to your healthcare service provider. Specially inform your Health care supplier if you are taking:

Due to these variations in valproate clearance, monitoring of valproate and concomitant drug concentrations should be greater Anytime enzyme inducing prescription drugs are launched or withdrawn.